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KMID : 0880520070430010013
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Chonnam Medical Journal
2007 Volume.43 No. 1 p.13 ~ p.18
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The Long-Term Clinical Effects of Elevated Troponin during Percutaneous Coronary Intervention to Predict Long-Term Clinical Outcome in Patients with Acute Coronary Syndrome
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Kim Ju-Han
Jeong Myung-Ho
Hong Young-Joon
Moon Jae-Youn
Ahn Young-Keun
Cho Jeong-Gwan
Park Jong-Chun
Kang Jung-Chaee
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Abstract
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The purpose of the study was to evaluate the effects of myocardial injury during percutaneous coronary intervention (PCI) on the long-term clinical outcome in patients with acute coronary syndrome (ACS) using cardiac troponin. Four hundred twenty four patients (61+/-10 year-old, 316 male) who underwent successful PCI with ACS, serum creatinine kinase isoenzyme MB (CK-MB), cardiac troponin T (cTnT) and I (cTnI) were measured before and at 6, 12, 24 hours after PCI. Patients were divided into two groups: Group I, elevated cTn and Group II, normal cTn after PCI. Major advanced cardiac events (MACE) were compared during 12-month clinical follow-up between both groups. Stenting was performed in 261 patients (62%) and ballooning in 163 patients (38%). The level of CK-MB was elevated in 89 patients (21%), cTnT in 118 patients (28%) and cTnI in 99 patients (23%) after PCI. MACE occurred in 47 patients (29%; revascularization in 42, acute myocardial infarction in 1, death in 4 patients) of Group I and in 39 patients (15%; revascularization in 37, acute myocardial infarction in 2 patients) of Group II (p<0.005) during 12-month clinical follow-up. The elevated cTn during PCI in patients with ACS is related to adverse effects on long-term prognosis
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KEYWORD
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Coronary disease, Myocardium, Myoglobin, Angioplasty, Prognosis
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